Affiliation:
1. Department of Biophysical Chemistry, Graduate School of Pharmaceutical Science, Tohoku University
2. JST, PRESTO
Abstract
AbstractThis paper reports that a combined Brønsted base (t-BuOLi/CsF or LiOCEt3/CsF) system mediates the 1,5-double-carboxylation of nonfused 2-alkylhetarenes at both the benzylic and δ-positions. A wide range of functional groups (OMe, F, Cl, CF3, OCF3, sulfide, CN, amide, ketone, or sulfone) are tolerated under the established reaction conditions.
Funder
Japan Society for the Promotion of Science
Environmental Restoration and Conservation Agency
Japan Science and Technology Agency
New Energy and Industrial Technology Development Organization
Daicel Corp.
Japan Agency for Medical Research and Development
Cited by
4 articles.
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