Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE Strategy-Reference-Cited by-同舟云学术

Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE Strategy

Published:2020-10-15 Issue:03 Volume:32 Page:283-286
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Vanelle Patrice¹,Ibrahimi Maroua²,Khoumeri Omar¹,Abderrahim Raoudha²,Terme Thierry¹

Affiliation:

1. Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire

2. University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Ressources Matériaux, Valorisation et Écosystème (RME code LR19ES20)

Abstract

AbstractA one-pot synthesis of new 3-benzylphthalide derivatives was developed by using a strategy based on tetrakis(dimethylamino)ethylene (TDAE). The reactions in the presence of TDAE of substituted benzyl chlorides with methyl 2-formylbenzoate or of substituted methyl-2-formylbenzoates with 4-nitrobenzyl chloride furnished the corresponding isobenzofuran-1(3H)-one products in moderate to good yields.

Funder

Centre National de la Recherche Scientifique

Aix-Marseille Université

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1290-8349.pdf

Reference3 articles.

1. Isolation of Spirastrellolides A and B from a Marine Sponge Epipolasis sp. and Their Cytotoxic Activities

2. Thunberginols A, B, and F, new antiallergic and antimicrobial principles from Hydrangeae Dulcis Folium.

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