Recombinant Human TSH Increases Uptake and Effective Half-life of Radioiodine in Thyroid Hormone Secreting Metastases of Follicular Thyroid Cancer

Author:

Schneider C.1,Dietlein M.1,Eschner W.2,Schmidt M.1,Kahraman D.1,Kobe C.1

Affiliation:

1. University Hospital of Cologne, Department of Nuclear Medicine, Cologne, Germany

2. University of Cologne, Department of Nuclear Medicine, Cologne, Germany

Abstract

AbstractFollicular thyroid cancer with thyroid hormone secreting metastases is an extremely rare condition, with only a few cases reported world-wide.We here present the case of a 64-year-old female patient affected by follicular thyroid cancer with extensive thyroid hormone secreting metastases leading to TSH-suppression.We have also summarized the relevant diagnostic and therapeutic approaches and describe, for the first time, the effects of rhTSH-application in this rare tumor entity.In this patient, we found that rhTSH increased 131I-uptake into the thyroid hormone secreting metastases and prolonged the effective half-life of 131I. These effects of rhTSH should be considered when fixed activities of 131I are prescribed.

Publisher

Georg Thieme Verlag KG

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine

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