Abstract
AbstractThe reduction of nitro compounds into the highly valuable anilines is reported using a Cu catalyst and B2Pin2. The reactions proceed under very mild conditions and showcase excellent functional group tolerance. This method is applied to a large panel of nitro derivatives, including biorelevant molecules and important synthetic intermediates, toward the synthesis of active pharmaceutical ingredients (APIs). This novel reaction manifold intends to provide a complementary approach to the existing portfolio of nitro-reduction methods.
Funder
Région Normandie
Agence National pour la Recherche
Chinese Scholarship Council
Normandie Université
Centre National de la Recherche Scientifique
Université de Rouen Normandie
Institut National des Sciences Appliquées Rouen Normandie
Labex SynOrg
XL-Chem Graduate School for Research
Innovation Chimie Carnot
Institut Universitaire de France