Disilathiane as a Sulfur Source for the Construction of Isothiochromenes and Benzo[b]thiophenes by Copper-Catalyzed endo-Selective Hydrothiolation

Abstract

AbstractA copper-catalyzed construction of isothiochromenes and benzo[b]thiophenes via annulation with 1,1,1,3,3,3-hexamethyldisilathiane as a sulfur source is described. In the isothiochromene synthesis, the use of the disilathiane as a sulfur source successfully controls the regioselectivity of cyclization to afford the isothiochromene as the sole product. The present strategy can be applied to the synthesis of 2-aryl/2-alkylbenzo[b]thiophenes.