4 Flow Photochemistry in Organic Synthesis

Abstract

AbstractPerforming photochemical reactions in flow has helped increase their efficiency, scalability, and utility. These efforts have brought photochemistry back to prominence as a powerful tool for synthesis. This chapter outlines the most important procedures and flow setups that can be used to perform photochemical transformations. Examples include ultraviolet-light-driven photocycloadditions and reactions with reagents such as singlet oxygen and transition-metal catalysts. Applications of visible-light photoredox catalysis in continuous-flow systems are discussed in the context of late-stage fluorination, natural product synthesis, alkyl–aryl cross coupling, and lignin fragmentation.