11 Immobilized Catalysts for Asymmetric Reactions

Abstract

AbstractRecent applications of polymer-immobilized catalysts for asymmetric reactions are described in this chapter. The chiral catalysts covered include organocatalysts, Lewis acid catalysts, and transition-metal catalysts. Preparation of these chiral polymer-immobilized catalysts and their use in asymmetric reactions are described. The polymer-immobilized catalysts are insoluble in the solvent used for asymmetric reactions and are easily separated from the reaction mixture; the recovered polymeric catalysts can be reused many times without any loss of the catalytic performance. Some of these polymeric catalysts have been used in continuous-flow systems, potentially providing a powerful tool for the synthesis of optically active fine chemicals.