2.11 Radical–Radical Cross-Coupling Reactions

Abstract

AbstractDue to nearly diffusion-limited radical–radical coupling, synthetically useful, selective radical–radical cross-coupling reactions remain challenging. However, different radical lifetimes and various radical initiation approaches now provide the possibility for radical–radical cross-coupling. In this chapter, recent advances in radical–radical cross-coupling reactions are described. In the first part, a basic kinetic phenomenon called the persistent radical effect is briefly reviewed and explained. The remainder of the chapter presents a series of case studies, illustrating several types of radical–radical cross couplings in a variety of disparate settings.