Affiliation:
1. Division of Perinatology, Department of Obstetric and Gynecology,
Ankara Bilkent City Hospital, Cankaya, Turkey
2. Obstetrics and Gynecology, Ankara Bilkent City Hospital, Cankaya,
Turkey
3. Department of Obstetrics and Gynecology, Division of Perinatology,
Ankara City Hospital, Cankaya, Turkey
4. Department of Obstetrics and Gynecology, Division of Perinatology,
University of Health Sciences, Istanbul, Turkey
Abstract
Abstract
Objective To evaluate the utility of the neutrophil-to-lymphocyte ratio
(NLR), systemic immune-inflammation index (SII), and systemic immune-response
index (SIRI) in the prediction of adverse pregnancy outcomes in pregnant women
with Familial Mediterranean fever (FMF)
Material and methods This retrospective case-control study was conducted
between 2019–2023. First-trimester NLR, SII (NLR X platelet count), and
SIRI (NLR X monocyte count) values were compared between pregnant women with FMF
(n=85) and without FMF (n=105). Thereafter, pregnant women with
FMF were divided into two groups: 1) FMF with perinatal complications
(n=30), and 2) FMF without perinatal complications (n=55). NLR,
SII, and SIRI values were compared between the two subgroups. Finally, an ROC
analysis was performed to determine optimal cut-off values for NLR, SII, and
SIRI in the prediction of composite adverse pregnancy outcomes.
Results The FMF group had significantly higher first-trimester NLR, SII,
and SIRI values compared to the controls. The FMF with perinatal complications
group had significantly higher NLR, SII, and SIRI values than the FMF group
without perinatal complications (p<0.05). Optimal cut-off values were
4.89 (80% sensitivity, 78.2% specificity), 1180.6 (76.7%
sensitivity, 72.7% specificity), and 1.9 (83.3%
sensitivity,72.7% specificity) for NLR, SII, and SIRI, respectively.
Conclusion SII, SIRI, and NLR may be used to predict adverse pregnancy
outcomes in pregnant women with FMF.
Subject
Maternity and Midwifery,Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health