A Concise Total Synthesis of (±)-Stepharine and (±)-Pronuciferine-Reference-Cited by-同舟云学术

A Concise Total Synthesis of (±)-Stepharine and (±)-Pronuciferine

Published:2022-11-22 Issue: Volume: Page:
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Chen Ruiming¹,Jia Shihu¹,Cheng Hong-Gang¹^ORCID,Zhou Qianghui¹²³,Man Yuning¹

Affiliation:

1. Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric Opto-Electronic Materials, College of Chemistry and Molecular Sciences, The Institute for Advanced Studies, Wuhan University

2. TaiKang Center for Life and Medical Sciences, Wuhan University

3. State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences

Abstract

AbstractA concise total synthesis of (±)-stepharine and (±)-pronuciferine using readily available reagents as the starting materials is reported. This synthesis features a three-component Catellani reaction/Au-catalyzed 6-exo-dig cyclization for the assembly of 1-methylene-tetrahydroisoquinoline scaffold and an oxidative dearomatization for constructing spiro-cyclohexadienone scaffold.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Fundamental Research Funds for the Central Universities

Wuhan University

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1984-0755.pdf

Reference10 articles.