Affiliation:
1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid
Sadoughi University of Medical Sciences, Yazd, Iran
2. Pharmaceutical Science Research Center, Shahid Sadoughi University of
Medical Sciences, Yazd, Iran
Abstract
AbstractMinocycline, widely used as an antibiotic, has recently been found to have an
anti-inflammatory, neuroprotective and anticonvulsant effects. This study was
aimed to investigate the anticonvulsant effect of acute administration of
minocycline on pentylenetetrazole (PTZ)-induced seizures considering the
possible involvement of 5-HT3 receptor in this effect. For this
purpose, seizures were induced by intravenous PTZ infusion. All drugs were
administrated by intraperitoneal (i.p.) route before PTZ injection. Also,
1-(m-chlorophenyl)-biguanide (mCPBG, a 5-HT3 receptor agonist) and
Tropisetron (a 5-HT3 receptor antagonist) were used
45 minutes before minocycline treatment. Our results demonstrate that
acute minocycline treatment (80 and 120 mg/kg) increased the
seizure threshold. In addition, the 5-HT3 antagonist, tropisetron, at
doses that had no effect on seizure threshold, augmented the anticonvulsant
effect of minocycline (40 mg/kg), while mCPBG
(0.2 mg/kg) blunted the anticonvulsant effect of minocycline
(80 mg/kg). In conclusion, our findings revealed that the
anticonvulsant effect of minocycline is mediated, at least in part, by
inhibition of 5-HT3 receptor.
Subject
Drug Discovery,General Medicine
Cited by
2 articles.
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