Author:
Zdrojowy-Wełna Aleksandra,Valassi Elena
Abstract
AbstractManagement of Cushing’s syndrome (CS) can be particularly challenging in older
patients, compared with younger individuals, due to the lack of several clinical
features associated with cortisol excess along with a greater burden of
associated comorbidities. Moreover, the interpretation of diagnostic tests could
be influenced by age-related physiological changes in cortisol secretion. While
mortality is higher and quality of life is more impaired in the elderly with CS
as compared with the younger, there is currently no agreement on the most
effective therapeutic options in aged individuals, and safety data concerning
medical treatment are scanty. In this review, we summarize the current knowledge
about age-related differences in CS etiology, clinical presentation, treatment,
and outcomes and describe the potential underlying mechanisms.
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