Affiliation:
1. Chemical Process Development, Bristol Myers Squibb
2. The Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Dept. of Chemistry, The University of Texas at San Antonio
Abstract
AbstractA general Pd-catalyzed approach for the conversion of phenols into benzonitriles via aryl imidazolylsulfonates with a non-toxic cyanide source, potassium ferrocyanide, has been developed. Salient features of this method include low palladium precatalyst loadings (as low as 1.0 mol% total Pd), mild reaction conditions, and environmentally benign by-products compared to other (pseudo)halide aryl electrophiles. The initial scope of the reaction on a range of phenolic precursors is demonstrated including a one-pot, two-step approach to convert phenols directly into benzonitriles.
Funder
Max and Minnie Tomerlin Voelcker Fund
National Science Foundation, USA