Affiliation:
1. Department of Chemistry, School of Science and Technology, Kwansei Gakuin University
Abstract
AbstractThe development of novel synthetic methods for quaternary ammonium salts is highly demanded since the current synthesis heavily relies on the conventional Menshutkin reaction. Herein, we report photoredox-catalyzed alkylation of α-brominated alkenylammonium salts. Mechanistically, the generation of a highly reactive α-ammoniovinyl radical is the key to our method. This reaction enables the synthesis of various unprecedented α-alkylated alkenylammonium salts.
Funder
Japan Science and Technology Agency
Japan Society for the Promotion of Science
Ube Industries
Takeda Science Foundation
Astellas Foundation for Research on Metabolic Disorders
Uehara Memorial Foundation