Crosstalk in the Retinal Neurovascular Unit – Lessons for the Diabetic Retina-Reference-Cited by-同舟云学术

Crosstalk in the Retinal Neurovascular Unit – Lessons for the Diabetic Retina

Published:2012-03-08 Issue:04 Volume:120 Page:199-201
ISSN:0947-7349
Container-title:Experimental and Clinical Endocrinology & Diabetes
language:en
Short-container-title:Exp Clin Endocrinol Diabetes

Author:

Feng Y.¹²,Busch S.²,Gretz N.³,Hoffmann S.³,Hammes H.-P.²

Affiliation:

1. Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, University of Heidelberg, Germany

2. 5th Medical Department, Medical Faculty Mannheim, University of Heidelberg, Germany

3. Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Germany

Abstract

AbstractDiabetic retinopathy shares important features with neurodegenerative retinal diseases, including loss of ganglion cells and retinal thinning. The impact on vasoregression and subsequent ischemia-driven changes such as macular edema and proliferative retinopathy are not established. Studies using adult neurodegenerative animal models such as the transgenic TGR(CMV-PKD2(1/703)HA) rat imply early activation of the innate immunity system and the complement system as well as microglia playing a role in the damage of the retinal neurovascular unit.

Publisher

Georg Thieme Verlag KG

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0032-1304571

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