Affiliation:
1. School of Food Science and Bioengineering, Xihua University
2. Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences
3. YaoPharma, Co., Ltd.
Abstract
AbstractPractical methods for the synthesis of three stereoisomers of Entecavir have been developed. Starting from the reported intermediate (1S,2R)-2-((benzyloxy)methyl)cyclopent-3-en-1-ol and (1R,2S)-2-((benzyloxy)methyl)cyclopent-3-en-1-ol, respectively, three stereoisomers of Entecavir have been prepared with 17–20% overall yields. In principle, other stereoisomers could also be prepared by using the materials and reactions described in this article.
Subject
Organic Chemistry,Catalysis