Abstract
AbstractThe synthesis of trifunctional isomeric benzothiazoles derived from nitroanthranilic acids and their corresponding anthranilonitrile analogues is studied. Compared to previous work, the reaction sequence affords convenient access to hitherto undescribed 2-cyanobenzothiazoles. For further synthetic applications of these polyfunctional compounds, a hydrolysis–decarboxylation sequence is performed in an acidic medium (HCl or HBr), leading to an enlarged array of relevant building blocks.
Funder
Université de Rouen Normandie
Institut National des Sciences Appliquées Rouen Normandie
Centre National de la Recherche Scientifique
European Regional Development Fund
Labex SynOrg
Institut Carnot I2C
XL-Chem Graduate School of Research
Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation
Région Normandie
Subject
Organic Chemistry,Catalysis