Review of the Total Synthesis of the Aromatic Abietane Diterpenoid Ferruginol

Abstract

AbstractThe biological properties and synthesis of ferruginol as a classical abietane-type diterpenoid with an aromatic C ring are reviewed. A strategy overview from 1954 to 2023 toward the total synthesis of ferruginol may provide some references for the future design and synthesis of new diterpenoids natural products.1 Introduction2 Biological Activity of Ferruginol3 Strategies toward the Total Synthesis of Ferruginol3.1 Bogert–Cook Synthesis3.2 Robinson Annulation3.3 Domino Synthesis3.4 Intramolecular Friedel–Crafts Alkylation3.5 Oxidative Free-Radical Cyclization3.6 Polyene Cyclization4 Conclusion and Perspectives