Neurosurgical Management of Patients with Alpha-Gal Syndrome

Author:

Carlstrom Lucas P.1ORCID,Akhter Asad1,Macielak Robert J.2,Callejas Claudio A.2,Eickstaedt Jennifer E.3,Brooks Christopher4,Koevering Kyle Van2,Schoo Desi2,Wu Kyle C.1,Prevedello Daniel M.1

Affiliation:

1. Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

2. Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

3. Department of Clinical Pharmacology, Mayo Clinic, Rochester, Minnesota, United States

4. Department of Allergy and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

Abstract

AbstractAlpha-gal syndrome (AGS) is an immunoglobulin E–mediated hypersensitivity to galatcose-alpha-1,3-galactose (alpha-gal), a carbohydrate compound present in nonprimate mammalian products. Initial exposure to alpha-gal most often occurs through a tick bite, most commonly the lone star tick in the United States. Repeated exposure to alpha-gal may elicit severe allergic reactions, including anaphylaxis. The allergy restricts dietary intake and may significantly impact perioperative risk, as many medications, anesthetics, and intraoperative surgical products utilize bovine or porcine-derived agents, including those containing magnesium stearate, glycerol, and gelatin. Here, we review the perineurosurgical care of two individuals with AGS and highlight pertinent clinical practices and perioperative management of these patients.

Publisher

Georg Thieme Verlag KG

Reference12 articles.

1. Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients;S P Commins;Expert Rev Clin Immunol,2020

2. Allergic response to medical products in patients with alpha-gal syndrome;K V Kuravi;J Thorac Cardiovasc Surg,2022

3. What is alpha-gal syndrome?;F Mollah;JAMA,2024

4. Perioperative considerations in alpha-gal syndrome: a review;J Leder;Cureus,2024

5. The α-gal syndrome and potential mechanisms;P Román-Carrasco;Front Allergy,2021

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3