Update Breast Cancer 2022 Part 3 – Early-Stage Breast Cancer-Reference-Cited by-同舟云学术

Update Breast Cancer 2022 Part 3 – Early-Stage Breast Cancer

Published:2022-09 Issue:09 Volume:82 Page:912-921
ISSN:0016-5751
Container-title:Geburtshilfe und Frauenheilkunde
language:de
Short-container-title:Geburtshilfe Frauenheilkd

Author:

Fehm Tanja N.¹,Welslau Manfred²,Müller Volkmar³,Lüftner Diana⁴,Schütz Florian⁵,Fasching Peter A.⁶,Janni Wolfgang⁷,Thomssen Christoph⁸,Witzel Isabell³,Belleville Erik⁹,Untch Michael¹⁰,Thill Marc¹¹,Tesch Hans¹²,Ditsch Nina¹³,Lux Michael P.¹⁴,Aktas Bahriye¹⁵,Banys-Paluchowski Maggie¹⁶,Schneeweiss Andreas¹⁷,Kolberg-Liedtke Cornelia¹⁸,Hartkopf Andreas D.⁷,Wöckel Achim¹⁹,Kolberg Hans-Christian²⁰,Harbeck Nadia²¹,Stickeler Elmar²²

Affiliation:

1. Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

2. Onkologie Aschaffenburg, Aschaffenburg, Germany

3. Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

4. Immanuel Hospital Märkische Schweiz & Medical University of Brandenburg Theodor-Fontane, Brandenburg, Buckow, Germany

5. Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

6. Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

7. Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

8. Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

9. ClinSol GmbH & Co KG, Würzburg, Germany

10. Clinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

11. Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt am Main, Germany

12. Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany

13. Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany

14. Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Germany

15. Department of Gynecology, University of Leipzig Medical Center, Leipzig, Germany

16. Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

17. National Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany

18. Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

19. Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

20. Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

21. Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

22. Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany

Abstract

AbstractThis review summarizes recent developments in the prevention and treatment of patients with early-stage breast cancer. The individual disease risk for different molecular subtypes was investigated in a large epidemiological study. With regard to treatment, new data are available from long-term follow-up of the Aphinity study, as well as new data on neoadjuvant therapy with atezolizumab in HER2-positive patients. Biomarkers, such as residual cancer burden, were investigated in the context of pembrolizumab therapy. A Genomic Grade Index study in elderly patients is one of a group of studies investigating the use of modern multigene tests to identify patients with an excellent prognosis in whom chemotherapy may be avoided. These and other aspects of the latest developments in the diagnosis and treatment of breast cancer are described in this review.

Publisher

Georg Thieme Verlag KG

Subject

Maternity and Midwifery,Obstetrics and Gynecology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1912-7105.pdf

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