Facile Strategy to Access the Indolo[2,3-a]quinolizidine Framework: Synthetic Study on Tangutorine
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Published:2019-07-24
Issue:19
Volume:51
Page:3715-3722
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ISSN:0039-7881
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Container-title:Synthesis
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language:en
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Short-container-title:Synthesis
Author:
Reddy Chada Raji12,
Warudikar Kamalkishor12,
Latha Bellamkonda1
Affiliation:
1. Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology
2. Academy of Scientific and Innovative Research (AcSIR)
Abstract
An asymmetric synthetic approach to indolo[2,3-a]quinolizidine framework has been developed involving Horner–Wadsworth–Emmons olefination and reductive amination as the key steps. Further, the developed strategy was explored towards the synthesis of tangutorine using Evans aldol reaction for the preparation of desired aldehyde.
Funder
Council of Scientific and Industrial Research
Publisher
Georg Thieme Verlag KG
Subject
Organic Chemistry,Catalysis