DMSO-Mediated Synthesis of Methylene-Bridged Unsymmetrical Bisamides in the Presence of AcOH-Reference-Cited by-同舟云学术

DMSO-Mediated Synthesis of Methylene-Bridged Unsymmetrical Bisamides in the Presence of AcOH

Published:2019-10-09 Issue:02 Volume:52 Page:297-303
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Zhang Yi¹²,Zhou Dongheng¹,Ma Yongmin¹²,Chen Jing¹

Affiliation:

1. School of Pharmaceutical Science, Zhejiang Chinese Medical University

2. School of Pharmaceutical and Chemical Engineering, Taizhou University

Abstract

A simple and efficient procedure for the synthesis of N-[(methylthio)methyl]benzamides and methylene-bridged unsymmetrical bisamides was achieved mediated by DMSO in the presence of acetic acid. DMSO plays a dual role in the transformation, as not only a solvent, but also an environmentally benign methylene source. The protocol provides new strategies for effective synthesis of unsymmetrical bisamides and avoids the use of transition-metal catalysts.

Funder

Natural Science Foundation of Zhejiang Province

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1690031.pdf

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