Synthesis of 4-Nitroisoxazoles via NO/NO2-Mediated Heterocyclization of Aryl-Substituted α,β-Unsaturated Ketones-Reference-Cited by-同舟云学术

Synthesis of 4-Nitroisoxazoles via NO/NO2-Mediated Heterocyclization of Aryl-Substituted α,β-Unsaturated Ketones

Published:2020-02-03 Issue:09 Volume:52 Page:1398-1406
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Averina Elena B.¹²,Vasilenko Dmitry A.¹,Sadovnikov Kirill S.¹,Sedenkova Kseniya N.¹²,Kurova Anastasiya V.¹,Grishin Yuri K.¹,Kuznetsova Tamara S.¹,Rybakov Victor B.¹,Volkova Yulia A.¹³

Affiliation:

1. Department of Chemistry, Lomonosov Moscow State University

2. Institute of Physiologically Active Compounds

3. N.D. Zelinsky Institute of Organic Chemistry RAS

Abstract

A straightforward approach for the synthesis of 4-nitroisoxazoles has been developed via heterocyclization of aryl/hetaryl-substituted α,β-unsaturated ketones upon treatment with tetranitromethane-triethylamine (TNM-TEA) complex or t-BuONO. This strategy features high efficiency and wide substrate tolerance under simple reaction conditions.

Funder

Russian Science Foundation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1690053.pdf

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