Affiliation:
1. College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University
Abstract
A copper(I)-mediated tandem three-component reaction using alkynes, azides, allyl iodides, CuI and NaNH2 is developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further converted into 1,2,3-triazole-fused tricyclic scaffolds. This method features an efficient one-pot cascade route using commercial alkynes and affords the corresponding 5-allyl-1,2,3-triazoles with high yields and good selectivity under mild reaction conditions.
Funder
National Research Foundation of Korea
Subject
Organic Chemistry,Catalysis
Cited by
6 articles.
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