Sedation During Neurocritical Care

Author:

Vanaclocha Nieves1,Chisbert Vicente2,Quilis Vicent345,Bilotta Federico6,Badenes Rafael7

Affiliation:

1. Department of Plastic Reconstructive Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain

2. Escuela de Doctorado, Universidad Católica de Valencia, “San Vicente Mártir,” Spain

3. Department of Neurosurgery, Hospital Clínic Universitari de València, Spain

4. College of Medicine and Science, Mayo Clinic, United States

5. Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Spain

6. Department of Anesthesiology, University of Rome “La Sapienza,” Rome, Italy

7. Department of Anesthesiology and Surgical-Trauma Intensive Care, Hospital Clinic Universitari Valencia, University of Valencia, Spain

Abstract

AbstractSedation is an essential therapeutic strategy in the care of neurocritical patients. Intravenous sedative agents are the most widely used, with promising alternatives (dexmedetomidine, ketamine, and volatile agents) to propofol and midazolam arising. Studies designed to evaluate superiority and avoid biases are required. A neurological awakening test is safe in most patients. Potential risks and benefits of limiting deep sedation and daily interruption of sedation in these patients remain unclear. The aim of this review was to report recent clinical evidence on sedation in this subgroup of patients, focusing on its effects on clinical prognosis.

Publisher

Georg Thieme Verlag KG

Subject

Anesthesiology and Pain Medicine,Neurology (clinical),Critical Care and Intensive Care Medicine

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