Synthesis of Fully Substituted Pyrroles through a Copper-Catalyzed Aza-Michael/Claisen Rearrangement/Cyclization Cascade-Reference-Cited by-同舟云学术

Synthesis of Fully Substituted Pyrroles through a Copper-Catalyzed Aza-Michael/Claisen Rearrangement/Cyclization Cascade

Published:2020-01-29 Issue:07 Volume:31 Page:723-729
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Tan Hao¹,Jiang Xue-Fei¹,Jiang Lu¹,Yuan Chang¹,Tang Xue¹²,Li Meng-Fan¹,Liu Si-Wei¹³,Liu Si¹,Cui Hai-Lei¹^ORCID

Affiliation:

1. Laboratory of Asymmetric Synthesis, Chongqing University of Arts and Sciences

2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine

3. Tonichem Pharmaceutical Technology Co., Ltd

Abstract

We have developed a copper-catalyzed aza-Michael/Claisen rearrangement/cyclization cascade sequence that affords structurally diverse pentasubstituted pyrroles in acceptable to good yields (31–84%).

Funder

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1691577.pdf

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