Affiliation:
1. RIKEN Cluster for Pioneering Research
2. RIKEN Center for Sustainable Resource Science
Abstract
In the reactions of simple starting materials, precise catalytic control of the stereochemical outcome (enantio- and diastereoselectivity), as well as chemoselectivity and regioselectivity is an efficient approach to increase molecular complexity with minimal use of protecting groups. Here, we introduce our ongoing studies on asymmetric catalytic reactions using α-keto esters as pronucleophiles or formal 1,3-dipolarophiles. Capitalizing on the high tunability of our late transition-metal complexes with a suitable basic counteranion, we have established a range of multiselective catalytic protocols starting from α-keto esters to provide a wide variety of stereochemically complex molecules incorporating adjacent stereocenters.1 Introduction2 Catalytic Asymmetric Monofluorination with NSFI3 Catalytic Asymmetric Michael Reaction with Nitroolefins4 Catalytic Asymmetric [3+2] Cycloaddition with (E)-Nitrones5 Catalytic Asymmetric [3+2] Cycloaddition with Nitrile Oxides6 Summary
Funder
Japan Society for the Promotion of Science
Cited by
11 articles.
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