Affiliation:
1. College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine
2. Chemistry Manufacture Control Department, Accendatech Co., Ltd.
Abstract
An efficient and general method for the synthesis of functionalized α,α-dihaloimines via halogenation of N-substituted enaminoesters and enaminones is described. This reaction, in which both α,α-dihaloimines and mixed α,α-dihaloimines could be achieved in good to excellent yields, is believed to proceed via an α-monohalogenated enamine intermediate. This synthetic method features no use of transition metals, readily accessible substrates, mild reaction conditions, simple and safe operation, and gram scale synthesis. Furthermore, the synthetic utility of the products was demonstrated by their efficient transformations to further useful nitrogen-containing heterocycles and building blocks.
Funder
National Major Science and Technology Projects of China
National Natural Science Foundation of China
Subject
Organic Chemistry,Catalysis
Cited by
2 articles.
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