Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N-Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water-Reference-Cited by-同舟云学术

Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N-Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water

Published:2019-12-16 Issue:03 Volume:31 Page:280-284
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Ding Xiaojuan¹,Zhang Lei¹,Mao Yiyang¹,Rong Binsen¹,Zhu Ning¹,Duan Jindian¹,Guo Kai¹²^ORCID

Affiliation:

1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University

2. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University

Abstract

The first Pd-catalyzed cyclization of N-aryl-2-aminopyridines with 2-iodobenzoic acids for the synthesis of phenanthridinones through C–H bond activation under very low catalyst loadings (down to 0.1 mol% Pd) in water is reported. This protocol features a broad substrate scope and provides easy efficient access to various phenanthridinones.

Funder

Natural Science Research of Jiangsu Higher Education Institutions of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1691538.pdf

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