Affiliation:
1. Department of Chemistry, Baburaoji Gholap College
Abstract
A simple and efficient protocol for base-mediated selective synthesis of 2-(arylamino)ethanols from primary aromatic amines and 2-aryloxyethanols from phenols, promoted by K2CO3 has been achieved under mild conditions. Even in presence of excess alkyl halide, selective mono-N-alkylation has been achieved. Tolerance of a variety of functional groups is demonstrated by 15 examples of selective N-alkylation of aromatic amines and 19 examples of O-alkylation of phenols. The efficacy of the protocol is demonstrated by the formal synthesis of Ticlopidine®, Vildagliptin®, Quetiapine®, and Gemfibrozil®.
Subject
Organic Chemistry,Materials Science (miscellaneous),Biomaterials,Catalysis
Cited by
2 articles.
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