Affiliation:
1. Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
2. College of Chemistry, Fuzhou University
3. University of Chinese Academy of Sciences
Abstract
AbstractIonic 1,4-difunctionalization of 1,3-enynes has often been conducted with strong nucleophiles or 1,3-enynes that are activated by an electron-withdrawing group. In this work, a palladium-catalyzed three-component ionic 1,4-carboarylation of 1,3-enynes is reported with arylated 1,3-enynes as the substrates. This method can afford various tetrasubstituted allenes with different functionalities. The palladium salt might play a key dual role in the reaction: as the catalyst to catalyze the cross-coupling reaction and as a Lewis acid to facilitate the nucleophilic attack. The synthetic value of this method is demonstrated by the further cyclization, decoration, and hydrolysis of the allene products.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Chinese Academy of Sciences
Subject
Organic Chemistry,Catalysis
Cited by
2 articles.
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