Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria-Reference-Cited by-同舟云学术

Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria

Published:2024-02-09 Issue: Volume: Page:
ISSN:0720-9355
Container-title:Hämostaseologie
language:de
Short-container-title:Hamostaseologie

Author:

Beckmann Lennart¹,Faizy Tobias D.²,Flottmann Fabian²,Fiehler Jens²,Bokemeyer Carsten¹,Well Lennart³,Beitzen-Heineke Antonia¹,Langer Florian¹

Affiliation:

1. Zentrum für Onkologie, II. Medizinische Klinik und Poliklinik, Universitätsklinikum Eppendorf, Hamburg, Germany

2. Zentrum für Radiologie und Endoskopie, Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Eppendorf, Hamburg, Germany

3. Zentrum für Radiologie und Endoskopie, Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie und Nuklearmedizin, Universitätsklinikum Eppendorf, Hamburg, Germany

Abstract

AbstractCase: Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare bone marrow disorder caused by acquired mutations in the phosphatidylinositol glycan class A gene, which lead to a partial or total loss of the cellular complement regulators CD55 and CD59.1 In addition to complement-mediated hemolysis and cytopenia, venous and arterial thromboses at multiple and/or unusual sites are a common complication and occur in up to 44% of patients in historic PNH cohorts.1 2

Publisher

Georg Thieme Verlag KG

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2231-5277.pdf

Reference4 articles.

1. Paroxysmal nocturnal hemoglobinuria: where we stand;J Panse;Am J Hematol,2023

2. Thrombosis in paroxysmal nocturnal hemoglobinuria;A Hill;Blood,2013

3. How I treat paroxysmal nocturnal hemoglobinuria;R A Brodsky;Blood,2021

4. A 15-year, single institution experience of anticoagulation management in paroxysmal nocturnal hemoglobinuria patients on terminal complement inhibition with history of thromboembolism;G F Gerber;Am J Hematol,2022

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1. Heparin;Reactions Weekly;2024-08-24