Effect of Yellow Propolis on Biocompatibility of Cements: Morphological and Immunohistochemistry Analysis

Author:

de Meneses Izaura Helena Chaves1,de Morais Sampaio Gêisa Aiane2,Vieira Rayssa Amaral3,da Silva Campos Márcio José3,Alves Polliana Muniz4,Pithon Matheus Melo5,Lacerda-Santos Rogério6ORCID

Affiliation:

1. Department of Dentistry, Dental School, Uniesp Centro Universitario, Cabedelo, Paraíba, Brazil

2. Department of Dentistry, Dental School, University of Pernambuco, Arcoverde, Pernambuco, Brazil

3. Graduate Program in Dentistry, Dental School, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil

4. Department of Pathology, Dental School, State University of Paraíba, Campina Grande, Paraíba, Brazil

5. Department of Orthodontics, State University of the Southwest of Bahia, Jéquie, Bahia, Brazil

6. Department of Orthodontics and Pediatric Dentistry, Dental School, Federal University of de Fora, Minas Gerais, Brazil

Abstract

Abstract Objective The focus of this study was to evaluate the biocompatibility of ionomer cements modified with ethanolic extracts of propolis (EEP) in different concentrations and time intervals. Materials and Methods In total, one hundred and thirty-five male Wistar rats were randomized into nine groups: Control, Groups Meron, and Groups Ketac (conventional, and added with 10, 25, 50% EEP, respectively). Histological analyses of inflammatory infiltrate and collagen fibers, and immunohistochemistry of CD68+ for macrophages (MOs) and multinucleated giant cells (MGCs) were performed. Statistical Analysis Data were analyzed using the Kruskal—Wallis and Dunn (p < 0.05) tests. Results Intense inflammatory infiltrate was demonstrated in the cements with 10% EEP at 7 days and 15 days (p < 0.05), only Group Ketac 10% EEP (p = 0.01) at 30 days. A smaller quantity of collagen fibers was observed in the cements with 10% EEP (p = 0.01) at 7 days, and Group Meron 10% EEP (p = 0.04) at 15 days. MOs and MGCs showed significant difference for the cements with 10% EEP (p = 0.01) at 7 and 15 days. At 30 days, MOs persisted in the Groups with 10% EEP. Conclusions The concentration of 10% EEP had the greatest influence on the inflammatory and tissue repair processes. The concentrations of 25 and 50% EEP demonstrated biocompatibility similar to that of cements that did not receive EEP.

Publisher

Georg Thieme Verlag KG

Subject

General Dentistry

Reference47 articles.

1. Antibacterial and mechanical properties of propolis added to glass ionomer cement;E Hatunoğlu;Angle Orthod,2014

2. In vivo biocompatibility, mechanical, and antibacterial properties of cements modified with propolis in different concentrations;I HC Meneses;Eur J Dent,2020

3. In vitro antibacterial effects of glass-ionomer cement containing ethanolic extract of propolis on Streptococcus mutans;N Topcuoglu;Eur J Dent,2012

4. Can we add chlorhexidine into glass ionomer cements for band cementation?;M M Farret;Angle Orthod,2011

5. Comparative evaluation of shear bond strength and fluoride release of conventional glass ionomer with 1% ethanolic extract of propolis incorporated glass ionomer cement—in vitro study;A R Prabhakar;J Clin Diagn Res,2016

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