Evaluation of the Neuroprotective Effect of Pycnogenol in a Hypoxic-Ischemic Brain Injury Model in Newborn Rats-Reference-Cited by-同舟云学术

Evaluation of the Neuroprotective Effect of Pycnogenol in a Hypoxic-Ischemic Brain Injury Model in Newborn Rats

Published:2021-05-27 Issue: Volume: Page:
ISSN:0735-1631
Container-title:American Journal of Perinatology
language:en
Short-container-title:Am J Perinatol

Author:

Çolak Ruya¹^ORCID,Celik Aslı²^ORCID,Diniz Gulden³^ORCID,Alkan Özdemir Senem⁴^ORCID,Yilmaz Osman²^ORCID,Calkavur Sebnem⁴^ORCID

Affiliation:

1. Neonatal Intensive Care Unit, Division of Pediatric, Medical Park Bahcelievler Hospital, Altınbas University Medical Faculty, Istanbul, Turkey

2. Department of Laboratory Animal Science, Faculty of Health Sciences, Dokuz Eylül University, Izmir, Turkey

3. Department of Pathology, Medical Faculty, Izmir Democracy University, Izmir, Turkey

4. Neonatal Intensive Care Unit, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey

Abstract

Objective This study aimed to evaluate the efficacy of Pycnogenol (PYC) and its antioxidant and antiapoptotic effect in an experimental hypoxic-ischemic (HI) rat model. Study Design A total of 24 Wistar albino rats who were on the seventh postnatal day were divided into three groups with developed HI brain injury model under the sevoflurane anesthesia: 40 mg/kg PYC was given to Group A, saline was given to Group B, and the sham group was Group C. Neuronal apoptosis was investigated by terminal deoxynucleotidyl transferase dUTP nick end labeling and immunohistochemically stained manually with primer antibodies of tumor necrosis factor-α and interleukin-1β. Results The neuronal cell injury was statistically lower in the PYC treatment group. Conclusion This is the first study that investigates the role of PYC in the HI brain injury model. PYC reduces apoptosis and neuronal injury in the cerebral tissue of the rats. PYC may be a protective agent against hypoxic-ischemic encephalopathy. Key Points

Publisher

Georg Thieme Verlag KG

Subject

Obstetrics and Gynaecology,Pediatrics, Perinatology, and Child Health

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0041-1730349.pdf

Reference29 articles.

1. Encefalopatía hipóxica-isquémica neonatal;O Papazian;Medicina (B Aires),2018

2. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy;J J Kurinczuk;Early Hum Dev,2010

3. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis;M A Tagin;Arch Pediatr Adolesc Med,2012

4. Hypothermia and neonatal encephalopathy;L A Papile;Pediatrics,2014

5. Pycnogenol: a blend of procyanidins with multifaceted therapeutic applications?;G D'Andrea;Fitoterapia,2010

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