What Is the Role of Steroids for Septic Shock in 2021?-Reference-Cited by-同舟云学术

What Is the Role of Steroids for Septic Shock in 2021?

Published:2021-09-20 Issue:05 Volume:42 Page:726-734
ISSN:1069-3424
Container-title:Seminars in Respiratory and Critical Care Medicine
language:en
Short-container-title:Semin Respir Crit Care Med

Author:

Nedel Wagner¹²,Lisboa Thiago³⁴⁵,Salluh Jorge I.F.⁶⁷

Affiliation:

1. Programa de Pós-Graduação em Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

2. Intensive Care Unit, Grupo Hospitalar Conceição, Porto Alegre, Brazil

3. Critical Care Department, Programa de Pós-Graduação em Ciencias Pneumologicas, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

4. Programa de Pós-Graduação em Saúde e Desenvolvimento Humano, Universidade Unilasalle, Canoas, Brazil

5. Instituto de Pesquisa, HCOR, São Paulo, Brazil

6. Department of Critical Care and Postgraduate Program in Translational Medicine, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil

7. Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Abstract

AbstractCorticosteroids have been used for decades in the adjunctive treatment of severe infections in intensive care. The most frequent scenario in intensive care is in septic shock, where low doses of glucocorticoids appear to restore vascular responsiveness to norepinephrine. There is a strong body of evidence suggesting that hydrocortisone reduces time on vasopressor, and may modulate the immune response. In this review, we explore the current evidence supporting the use of corticosteroids in septic shock, its benefits, and potential harms. In addition to landmark clinical trials, we will also describe new frontiers for the use of corticosteroids in septic shock which should be explored in future studies.

Publisher

Georg Thieme Verlag KG

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0041-1733900.pdf

Reference70 articles.

1. Steroid use in critical care;A Young;BJA Educ,2018

2. Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM);D Annane;Intensive Care Med,2017

3. Reduced cortisol metabolism during critical illness;E Boonen;N Engl J Med,2013

4. Reduced cortisol metabolism during critical illness;G Van den Berghe;N Engl J Med,2013

5. New insights into the controversy of adrenal function during critical illness;E Boonen;Lancet Diabetes Endocrinol,2015

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