Abstract
AbstractA synthetic approach toward (–)-tetrodotoxin (TTX) is described. Our approach features a stereoselective construction of the TTX core structure using the bicyclo[2.2.2]octane skeleton which was constructed via intramolecular Diels–Alder reaction of an o-quinone monoketal having the key functional groups. The robust asymmetric synthesis was achieved by an iridium-catalyzed dynamic kinetic resolution (DKR) of the aryl vinyl carbinol that could be easily prepared from a simple aromatic compound.
Funder
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development
Ministry of Education, Culture, Sports, Science and Technology
Cited by
1 articles.
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1. Looking Back on My Past;Journal of Synthetic Organic Chemistry, Japan;2023-02-01