Copper-Catalyzed Radical Cascade Annulation for the Preparation of Difluorinated Pyrrolidines and Piperidines

Abstract

AbstractIn this work, we developed a one-pot, copper-catalyzed aminodifluoroalkylation of enylaniline derivatives. This approach allows the catalytic construction of a broad range of pyrrolidines and piperidines substituted with a gem-difluoro moiety.