Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

Author:

Devi Asshaima Paramita12,Duong Thuc-Huy3,Ferron Solenn4,Beniddir Mehdi A.5,Dinh Minh-Hiep6,Nguyen Van-Kieu78,Pham Nguyen-Kim-Tuyen9,Mac Dinh-Hung10,Boustie Joël4,Chavasiri Warinthorn1,Pogam Pierre Le5ORCID

Affiliation:

1. Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand

2. Program in Biotechnology, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand

3. Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam

4. Université Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) – UMR 6226, Rennes, France

5. Équipe «Pharmacognosie-Chimie des Substances Naturelles», BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, Châtenay-Malabry, France

6. Management Board of Ho Chi Minh City Agricultural Hi-Tech Park, Binh Thanh, Ho Chi Minh City, Vietnam

7. Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam

8. Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam

9. Faculty of Environmental Science, Sai Gon University, Vietnam

10. Department of Organic Chemistry, VNU University of Science, Hoan Kiem, Hanoi, Vietnam

Abstract

AbstractThree new depsidones, parmosidones F – G (1 – 2), and 8′-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A – C (4 – 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1 and 2 in particular inhibited α-glucosidase with IC50 values of 2.2 and 4.3 µM, respectively, and are thus more potent than the positive control, acarbose.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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