Excessive Treadmill Training Produces different Cardiac-related MicroRNA Profiles in the Left and Right Ventricles in Mice

Author:

Yang Jing1,Xu Lin123,Yin Xin23,Zheng Yi Li3,Zhang Hai Peng23,Xu Sheng Jia1,Wang Wei1,Wang Sen4,Zhang Chen Yu3,Ma Ji Zheng1

Affiliation:

1. The Research Center of Military Exercise Science, The Army Engineering University of PLA, Nanjing, China

2. Department of Exercise and Heath, Nanjing Sport Institute, Nanjing, China

3. State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China

4. Department of Geriatric Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Abstract

AbstractHigh-volume training followed by inadequate recovery may cause overtraining. This process may undermine the protective effect of regular exercise on the cardiovascular system and may increase the risk of pathological cardiac remodelling. We evaluated whether chronic overtraining changes cardiac-related microRNA profiles in the left and right ventricles. C57BL/6 mice were divided into the control, normal training, and overtrained by running without inclination, uphill running or downhill running groups. After an 8-week treadmill training protocol, the incremental load test and training volume results showed that the model had been successfully established. The qRT-PCR results showed increased cardiac miR-1, miR-133a, miR-133b, miR-206, miR-208b and miR-499 levels in the left ventricle of the downhill running group compared with the left ventricle of the control group. Similarly, compared with the control group, the downhill running induced increased expression of miR-21, miR-17–3p, and miR-29b in the left ventricle. Unlike the changes in the left ventricle, no difference in the expression of the tested miRNAs was observed in the right ventricle. Briefly, our results indicated that overtraining generally affects key miRNAs in the left ventricle (rather than the right ventricle) and that changes in individual miRNAs may cause either adaptive or maladaptive remodelling with overtraining.

Funder

The Research Special Fund for PLA University of Science and Technology

The Research Innovation Program for College Graduates of Jiangsu Province

The Research Fund for Postgraduate in Military

The Natural Science Foundation of Jiangsu Province (2021).

Publisher

Georg Thieme Verlag KG

Subject

Orthopedics and Sports Medicine,Physical Therapy, Sports Therapy and Rehabilitation

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