Synthesis of Difluoromethyl-Substituted Quinazolines through Selective Difluoromethylation

Abstract

AbstractA highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield.