Author:
Gandhi Thirumanavelan,Ramkumar Alagumalai
Abstract
AbstractAn operationally simple and expeditious protocol for Ru(II)-catalyzed ortho-C(sp2)–H hydroxyalkylation of phthalazinones using commercially available ethyl glyoxalate in 2-Me-THF is reported. This greener approach involves the imine nitrogen on the phthalazinones as a directing group to effect the regioselective hydroxyalkylation. Ample examples of biologically relevant hydroxyalkylated phthalazinones were prepared, and relevant controlled studies were performed to decipher the reaction mechanism.
Funder
Science and Engineering Research Board
Vellore Institute of Technology, Chennai
Subject
Organic Chemistry,Catalysis