Triterpenoids from Alisma orientale and their NF-кB Inhibitory Activity

Author:

Yang Qian12,Li Yinqing34,Liu Xizi12,Han Shiyi12,Fan Siyang12

Affiliation:

1. State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China

2. Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China

3. Shineway Pharmaceutical Group Ltd., Shijiazhuang, PR China

4. Hebei key Laboratory of Famous Classical Formulas and TCM Quality Process Control, Shijiazhuang, PR China

Abstract

AbstractThe rhizome of Alisma orientale (sam.) Juz. is used in clinics for eliminating dampness, reducing edema, and promoting diuresis. This study aimed to elucidate the compounds and investigate their nuclear factor-kappa inhibitory activities in human embryonic kidney 293 cells. A new triterpene, alismaketone B (1); a new natural nortriterpene, noralisolic acid A (2); and 13 known protostane-type triterpenes were isolated from the rhizome of A. orientale. The new structures and their absolute configurations were established using HRESIMS, NMR, and electronic circular dichroism experiments. All isolated compounds were evaluated for their inhibitory activity on NF-κB. The compounds 8, 9, 10, and 14 showed moderate NF-κB inhibitory activities with their IC50 values being 64.7, 32.3, 47.3, and 37.3 μM, respectively.

Funder

National Natural Science Foundation of China

National Science and Technology Project of China

S&T Program of Hebei

Publisher

Georg Thieme Verlag KG

Subject

General Medicine

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