Free-Radical-Involved Trifluoromethylthiolation Cyclization of Alkenes To Access SCF3-Substituted Indolo[2,1-a]isoquinolines

Abstract

AbstractFree-radical-promoted tandem trifluoromethylthiolation of alkenes with AgSCF3, which provides an efficient protocol for the construction of SCF3-modified indolo[2,1-a]isoquinolines with moderate to good yields. A series of scaled-up experiments, other substrate transformations, and radical inhibition experiments were operated to verify the merit of this reaction system.