Author:
Al-Harrasi Ahmed,Takallou Ahmad,Al-Shidhani Sulaiman,Anwar Muhammad U.
Abstract
AbstractA one-pot and sequential Ugi/SNCsp2 four-component reaction was introduced for the synthesis of cycloalkene-fused [1,4]thiazepine derivatives. A variety of cyclic β-bromovinyl aldehyde with different sizes, amines, and isocyanides were reacted with thioglycolic acid. This approach can provide a practical and rapid access to the fused bioactive cycloalkene structures containing thiazepine, and peptide unit, which proved the achievement of a significant structural diversity. Further use of this method has been successfully applied in synthesizing a variety of quinoline-fused [1,4]thiazepines with satisfactory results. The practical nature of this approach was demonstrated by a gram-scale synthesis of a selected product.
Subject
Organic Chemistry,Catalysis
Cited by
2 articles.
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