Affiliation:
1. Department of Clinical and Experimental Medicine, University of
Insubria, Varese, Italy
Abstract
AbstractGraves’ disease is the most common cause of hyperthyroidism in iodine-replete
areas and is ultimately due to antibodies interacting with the TSH receptor on
thyroid follicular cells [TSH-receptor antibody (TRAb)]. Antithyroid drugs
(ATDs) belonging to the family of thionamides are the first-line treatment in
Europe. ATD treatment is commonly continued for 18–24 months. Its major
limitation is the high rate of relapses after drug withdrawal. Factors
particularly bound to subsequent relapses are the large thyroid volume, smoking
habit, persistence of TRAb in the circulation at the end of treatment, and the
post-partum period. Under these conditions, consideration should be given to a
definitive therapy for hyperthyroidism (radioiodine treatment, thyroidectomy),
particularly if the patient is at risk of cardiovascular complications that
might be exacerbated by persistence or recurrence of hyperthyroidism.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
36 articles.
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