Affiliation:
1. Institut für Ernährungsmedizin, Else Kröner-Fresenius-Zentrum für Ernährungsmedizin, Klinikum rechts der Isar, Technische Universität München, München,
Germany
2. Institut für KI und Informatik in der Medizin, Klinikum rechts der Isar, Technische Universität München, München, Germany
Abstract
AbstractAntibiotic therapies for the treatment of bacterial infections pose a particular challenge during pregnancy and breastfeeding. For Germany, there is hardly any information on the
frequency of antibiotic use during this phase. Our analysis uses data from the “Healthy Living in Pregnancy” (GeliS) study to describe antibiotic treatments during pregnancy and in the
first six months after birth (postpartum), and to compare their use with existing recommendations.This is a retrospective secondary analysis of the GeliS study. In the cluster randomized lifestyle intervention study, detailed information on antibiotic therapies during pregnancy and
postpartum was collected using surveys. Chi-square tests and generalized estimating equations were used for evaluation.Of the 1636 women included in the analysis, 21% reported antibiotic treatment at least once during pregnancy (14%) or in the first six months postpartum (7%). During pregnancy, the
antibiotic therapies of women increased from 1.7% in the first trimester to 6.5% in the third trimester. Common reasons for treatment were urinary tract infections (7.3% of women), ear,
nose, throat (ENT) infections (3.6%), and birth complications (2.6%). The information on the prescribed preparations corresponded to the current recommendations. A significant increase in
the frequency of treatment with antibiotics was observed in the lifestyle intervention group (p < 0.001), in participants without a partner (p < 0.001), and in women who breastfed
their children (p = 0.005) or gave birth by caesarean section (p = 0.003) or prematurely (p = 0.012). Other socioeconomic or lifestyle factors were not significant.Approximately one in five women receives at least one antibiotic treatment during pregnancy and breastfeeding that meets current treatment recommendations. Treatment with antibiotics is
more common in premature births, caesarean sections, and breastfeeding women.
Funder
DEDIPAC Konsortium
Bayerisches Staatsministerium für Gesundheit und Pflege
AOK Bayern
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin der Technischen Universität München
Kompetenzzentrum für Ernährung in Bayern
Bayerisches Staatsministerium für Ernährung, Landwirtschaft und Forsten
Else Kröner-Fresenius-Stiftung
Subject
Maternity and Midwifery,Obstetrics and Gynecology