Visible-Light-Promoted C(sp3)–H Bond Functionalization toward Aminothiazole Skeletons from Active Methylene Ketones and Thioureas-Reference-Cited by-同舟云学术

Visible-Light-Promoted C(sp3)–H Bond Functionalization toward Aminothiazole Skeletons from Active Methylene Ketones and Thioureas

Published:2023-02-14 Issue:13 Volume:55 Page:2091-2098
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Guo Haichang¹,Wang Lei¹²^ORCID,Zheng Renhua¹^ORCID,Hu Xiurong¹³,Jiang Huajiang¹

Affiliation:

1. School of Pharmaceutical and Chemical Engineering, Taizhou University

2. Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University

3. Department of Chemistry, Zhejiang Sci-Tech University

Abstract

AbstractA novel and efficient visible-light-induced method is developed for the one-pot synthesis of functionalized 2-aminothiazoles from easily accessible active methylene ketone derivatives and different thioureas at room temperature. The mild reaction conditions, green chemistry, straightforward work-up, and high yields of the products make this procedure useful for the construction of 2-aminothiazole derivatives.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2035-2873.pdf

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4. Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans

5. 2-Aminothiazole-Derived Opioids. Bioisosteric Replacement of Phenols

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