Modular Synthesis of Streptogramin Antibiotics-Reference-Cited by-同舟云学术

Modular Synthesis of Streptogramin Antibiotics

Published:2020-10-20 Issue:07 Volume:32 Page:647-654
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Li Qi¹,Seiple Ian B.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry and Cardiovascular Research Institute, University of California, San Francisco

Abstract

AbstractStreptogramins are antibiotics produced by several species of Streptomyces bacteria that are used in both human and veterinary medicine. Group A streptogramins comprise 23-membered macrocyclic polyketide/nonribosomal peptide hybrids for which several innovative fully synthetic routes have been developed. Herein we describe in detail our scalable routes to natural Group A streptogramins and we compare these routes to other reported syntheses.

Funder

National Institute of General Medical Sciences

David and Lucile Packard Foundation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1293-9655.pdf

Reference13 articles.

1. Antibiotic resistance: it’s bad, but why isn’t it worse?

2. The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery

3. Antibiotic Resistance ABC-F Proteins: Bringing Target Protection into the Limelight

4. Potential for Reduction of Streptogramin A Resistance Revealed by Structural Analysis of Acetyltransferase VatA

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