Recent Advances in the Total Synthesis of Prenylflavonoid and Related Diels–Alder Natural Products

Author:

Han Jianguang1,Jones Alexander2,Lei Xiaoguang23

Affiliation:

1. School of Pharmaceutical Science and Technology, Tianjin University

2. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, Peking University

3. National Institute of Biological Sciences (NIBS)

Abstract

This review summarizes the application of different strategies for the key Diels–Alder cycloaddition in prenylflavonoid and related Diels–Alder natural products synthesis, highlighting the application of novel methodologies and innovative strategies in the synthesis of these natural products and their analogues.1 Introduction2 Classical Conditions for the Diels–Alder Cycloaddition2.1 Thermal Promotion2.2 High-Pressure Promotion2.3 Brønsted Acid Catalysis3 Modern Approaches to the Diels–Alder Cycloaddition3.1 Electron-Transfer Initiation3.2 Silver-Nanoparticle Catalysis3.3 Chiral-Boron-Complex Promotion4 Conclusion

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

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