Affiliation:
1. Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh,
India
Abstract
AbstractSilymarin is a standardized extract obtained from seeds of Silybum marianum (SM)
belonging to the family Asteraceae. It is a flavonolignan complex and consists
of various compounds like silybin A silybin B, isosilybin A, isosilybin B,
silydianin, silychristin and isosilychristin. Silybin is the major active
component present in 60–70% of the silymarin extract. It has
been used traditionally for the treatment of various liver disorders like
cirrhosis, jaundice, and hepatitis. Silymarin possesses antioxidant and
anti-inflammatory properties and is responsible for its antitumor activity.
Other than hepatoprotective effect SM also possesses renoprotective,
anti-diabetic, neuroprotective, hypolipidemic, anti-atherosclerosis and
cardioprotective effects. Rather antimicrobial property of silymarin was
observed against specific microbes, fungi, and viruses. This manuscript covered
recent preclinical and clinical evidence of specific components silybin,
responsible for its efficacy and about clinical studies has been conducted so
far, which proven it’s safety and offers mild effect like nausea,
diarrhea and bloating. This review specifically focused on recent updates on its
active components therapeutic applications against complicated ailments not
covered in earlier reports.
Subject
Drug Discovery,General Medicine
Reference85 articles.
1. Plants and human health in the twenty-first century;I Raskin;Trends Biotechnol,2002
2. Biology of milk thistle (silybum marianum) and the management options for
growers in north-western Pakistan;M A Khan;Weed Biol Manag,2009
3. Genetic parameter variations among milk thistle, Silybum marianum varieties and
varietal sensitivity to infestation with seed-head weevil, Larinus latus
Herbst;ME S Ottai;Int J Agric Biol,2006
4. Silybin and silymarin--new effects and applications;V Kren;Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2005
5. Enhancement of silymarin and phenolic compound accumulation in tissue culture of
Milk thistle using elicitor feeding and hairy root cultures;AM M Gabr;J Genet Eng Biotechnol,2016
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